Blumer Lab Publications

Grabowska, D, Jayaraman, M, Kaltenbronn, KM, Sandiford, SL, Wang, Q, Jenkins, S, Slepak, VZ, Smith, Y, Blumer, KJ.  2008. Postnatal induction and subcellular localization of R7BP, a membrane-targeting subunit for the RGS7 family and Gbeta5 in brain.  Neuroscience 151: 969-82. PubMed / Journal

Gu. S., Anton, A, Salim, S, Blumer, KJ, Dessauer, CW, Heximer, SP. 2008.  Alternative translation initiation of human RGS2 yields a set of functionally distinct proteins.  Mol. Pharmacol. 73: 1-11. PubMed / Journal

Blumer, K.J., Thorner, J. 2007. An adrenaline (and gold?) rush for the GPCR community.  ACS Chem. Biol. 2(12) 783-786. PubMed / Journal

Osei-owusu, P, Sun, X, Drenan, RM, Steinberg, TH, Blumer, KJ. 2007. Regulation of RGS2 and second messenger signaling in vascular smooth muscle cells by cGMP-dependent protein kinase
J. Biol. Chem. 2007. 282: 31656-65. PubMed / Journal

Tank, J, Obst, M, Diedrich, A, Brychta, RJ, Blumer, KJ, Heusser, K, Jordan, J, Luft, FC, Gross, V. 2007. Sympathetic nerve traffic and circulating norepinephrine levels in RGS2-deficient mice.
Auton Neurosci. 2007 Oct 30;136(1-2):52-57. PubMed / Journal

Heximer, SP, Blumer, KJ. 2007.  RGS Proteins: Swiss army knives in seven-transmembrane domain receptor signaling networks. Sci. STKE, pe2. PubMed / Journal

Drenan RM, Doupnik CA, Jayaraman M, Buchwalter AL, Kaltenbronn KM, Huettner JE, Linder ME, Blumer KJ. 2006. R7BP augments the function of RGS7/Gbeta 5 complexes by a plasma membrane-targeting mechanism. J Biol Chem. 281(38): 28222-31 PubMed / Journal

Huber TB, Kwoh C, Wu H, Asanuma K, Godel M, Hartleben B, Blumer KJ, Miner JH, Mundel P, Shaw AS. 2006. Bigenic mouse models of focal segmental glomerulosclerosis involving pairwise interaction of CD2AP, Fyn, and synaptopodin. J Clin Invest. 116(5): 1337-45. PubMed / Journal

Kim K, Galletta BJ, Schmidt KO, Chang FS, Blumer KJ, Cooper JA. 2006. Actin-based motility during endocytosis in budding yeast. Mol Biol Cell. 17(3): 1354-63. PubMed / Journal

Obst, M, Tank, J, Plehm, R, Blumer, KJ, Diedrich, A, Jordan, J, Luft, FC, Gross, V. 2006. NO-dependent blood pressure regulation in RGS2-deficient mice.  Am J Physiol Regul Integr Comp Physiol., 290(4): p. R1012-R1019. PubMed / Journal

Overton MC, Chinault SL, Blumer KJ. 2005. Oligomerization of G protein-coupled receptors: Lessons from the yeast Saccharomyces cerevisiae. Eukaryot Cell., 4(12): 1963-70. PubMed / Journal

Chang FS, Han G-S, Carman GM, Blumer KJ. 2005.  A WASp-interacting type II phosphatidylinositol 4-kinase powers actin polymerization-dependent endosome motility. J. Cell Biol., 171: 131-42. PubMed / Journal

Gross V, Tank J, Obst M, Plehm R, Blumer KJ, Diedrich A, Jordan J, Luft FC. 2005. Autonomic nervous system and blood pressure regulation in RGS2-deficient mice. Am J Physiol Regul Integr Comp Physiol. 288(5): R1134-42. PubMed / Journal / Highlight

Drenan RM, Doupnik CA, Boyle MP, Muglia LJ, Huettner JE, Linder ME, Blumer KJ. 2005. Palmitoylation regulates plasma membrane-nuclear shuttling of R7BP, a novel membrane anchor for the RGS7 family. J Cell Biol. 169(4): 623-33. PubMed / Journal / Highlight

Sun X, Kaltenbronn KM, Steinberg TH, Blumer KJ. 2005. RGS2 is a mediator of nitric oxide action on blood pressure and vasoconstrictor signaling. Mol Pharmacol. 67(3): 631-9. PubMed / Journal

Harris IS, Treskov I, Rowley MW, Heximer S, Kaltenbronn K, Finck BN, Gross RW, Kelly DP, Blumer KJ, Muslin AJ. 2004. G-protein signaling participates in the development of diabetic cardiomyopathy. Diabetes 53(12): 3082-90. PubMed / Journal

Larminie C, Murdock P, Walhin JP, Duckworth M, Blumer KJ, Scheideler MA, Garnier M. 2004. Selective expression of regulators of G-protein signaling (RGS) in the human central nervous system. Brain Res Mol Brain Res. 122(1): 24-34. PubMed / Journal

Wild AC, Yu JW, Lemmon MA, Blumer KJ. 2004. The p21-activated protein kinase-related kinase Cla4 is a coincidence detector of signaling by Cdc42 and phosphatidylinositol 4-phosphate. J Biol Chem. 279(17):17101-10. PubMed / Journal / Highlight

Chinault SL, Overton MC, Blumer KJ. 2004. Subunits of a yeast oligomeric G protein-coupled receptor are activated independently by agonist but function in concert to activate G protein heterotrimers. J Biol Chem. 279(16): 16091-100. PubMed / Journal

Blumer KJ. 2004. Vision: the need for speed. Nature 427(6969): 20-1. PubMed / Journal

Blumer KJ, Cooper JA. 2003. Go ahead, break my symmetry! Nat Cell Biol. 5(12): 1048-9. PubMed / Journal

Faury G, Pezet M, Knutsen RH, Boyle WA, Heximer SP, McLean SE, Minkes RK, Blumer KJ, Kovacs A, Kelly DP, Li DY, Starcher B, Mecham RP. 2003. Developmental adaptation of the mouse cardiovascular system to elastin haploinsufficiency. J Clin Invest. 112(9): 1419-28. PubMed / Journal / Highlight

Overton MC, Chinault SL, Blumer KJ. 2003. Oligomerization, biogenesis, and signaling is promoted by a glycophorin A-like dimerization motif in transmembrane domain 1 of a yeast G protein-coupled receptor. J Biol Chem. 278(49): 49369-77. PubMed / Journal

Floyd DH, Geva A, Bruinsma SP, Overton MC, Blumer KJ, Baranski TJ. 2003. C5a receptor oligomerization. II. Fluorescence resonance energy transfer studies of a human G protein-coupled receptor expressed in yeast. J Biol Chem. 278(37): 35354-61. PubMed / Journal

Chinault SL, Blumer KJ. 2003. The C-terminal tail preceding the CAAX box of a yeast G protein gamma subunit is dispensable for receptor-mediated G protein activation in vivo. J Biol Chem. 278(23): 20638-44. PubMed / Journal

Chang FS, Stefan CJ, Blumer KJ. 2003. A WASp homolog powers actin polymerization-dependent motility of endosomes in vivo. Curr Biol. 13(6): 455-63. PubMed / Journal

Garnier M, Zaratin PF, Ficalora G, Valente M, Fontanella L, Rhee MH, Blumer KJ, Scheideler MA. 2003. Up-regulation of regulator of G protein signaling 4 expression in a model of neuropathic pain and insensitivity to morphine. J Pharmacol Exp Ther. 304(3): 1299-306. PubMed / Journal

Heximer SP, Knutsen RH, Sun X, Kaltenbronn KM, Rhee MH, Peng N, Oliveira-dos-Santos A, Penninger JM, Muslin AJ, Steinberg TH, Wyss JM, Mecham RP, Blumer KJ. 2003. Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice. J Clin Invest. 111(4): 445-52. PubMed / Journal / Highlight

Overton MC, Blumer KJ. 2002. Use of fluorescence resonance energy transfer to analyze oligomerization of G-protein-coupled receptors expressed in yeast. Methods. 27(4): 324-32. PubMed / Journal

Overton MC, Blumer KJ. 2002. The extracellular N-terminal domain and transmembrane domains 1 and 2 mediate oligomerization of a yeast G protein-coupled receptor. J Biol Chem. 277(44): 41463-72. PubMed / Journal

Heximer SP, Lim H, Bernard JL, Blumer KJ. 2001. Mechanisms governing subcellular localization and function of human RGS2. J Biol Chem. 276(17): 14195-203. PubMed / Journal

Rogers JH, Tsirka A, Kovacs A, Blumer KJ, Dorn GW 2nd, Muslin AJ. 2001. RGS4 reduces contractile dysfunction and hypertrophic gene induction in Galpha q overexpressing mice. J Mol Cell Cardiol. 33(2): 209-18. PubMed / Journal / Highlight

Wu C, Zeng Q, Blumer KJ, Muslin AJ. 2000. RGS proteins inhibit Xwnt-8 signaling in Xenopus embryonic development. Development. 127(13): 2773-84. PubMed / Journal

Overton MC, Blumer KJ. 2000. G-protein-coupled receptors function as oligomers in vivo. Curr Biol. 10(6): 341-4. PubMed / Journal

Manahan CL, Patnana M, Blumer KJ, Linder ME. 2000. Dual lipid modification motifs in G(alpha) and G(gamma) subunits are required for full activity of the pheromone response pathway in Saccharomyces cerevisiae. Mol Biol Cell. 11(3): 957-68. PubMed / Journal

Heximer SP, Srinivasa SP, Bernstein LS, Bernard JL, Linder ME, Hepler JR, Blumer KJ. 1999. G protein selectivity is a determinant of RGS2 function. J Biol Chem. 274(48): 34253-9. PubMed / Journal

Holly SP, Blumer KJ. 1999. PAK-family kinases regulate cell and actin polarization throughout the cell cycle of Saccharomyces cerevisiae. J Cell Biol. 147(4): 845-56. PubMed / Journal

Takesono A, Zahner J, Blumer KJ, Nagao T, Kurose H. 1999. Negative regulation of alpha2-adrenergic receptor-mediated Gi signalling by a novel pathway. Biochem J. 343 Pt 1: 77-85. PubMed / Journal

Rogers JH, Tamirisa P, Kovacs A, Weinheimer C, Courtois M, Blumer KJ, Kelly DP, Muslin AJ. 1999. RGS4 causes increased mortality and reduced cardiac hypertrophy in response to pressure overload. J Clin Invest. 104(5): 567-76. PubMed / Journal

Tamirisa P, Blumer KJ, Muslin AJ. 1999. RGS4 inhibits G-protein signaling in cardiomyocytes. Circulation. 99(3): 441-7. PubMed / Journal

Stefan CJ, Blumer KJ. 1999. A syntaxin homolog encoded by VAM3 mediates down-regulation of a yeast G protein-coupled receptor. J Biol Chem. 274(3): 1835-41. PubMed / Journal

Eby JJ, Holly SP, van Drogen F, Grishin AV, Peter M, Drubin DG, Blumer KJ. 1998. Actin cytoskeleton organization regulated by the PAK family of protein kinases. Curr Biol. 8(17): 967-70. PubMed / Journal

Druey KM, Sullivan BM, Brown D, Fischer ER, Watson N, Blumer KJ, Gerfen CR, Scheschonka A, Kehrl JH. 1998. Expression of GTPase-deficient Gialpha2 results in translocation of cytoplasmic RGS4 to the plasma membrane. J Biol Chem. 273(29): 18405-10. PubMed / Journal

Grishin AV, Rothenberg M, Downs MA, Blumer KJ. 1998. Mot3, a Zn finger transcription factor that modulates gene expression and attenuates mating pheromone signaling in Saccharomyces cerevisiae. Genetics. 149(2): 879-92. PubMed / Journal

Zhang S, Watson N, Zahner J, Rottman JN, Blumer KJ, Muslin AJ. 1998. RGS3 and RGS4 are GTPase activating proteins in the heart. J Mol Cell Cardiol. 30(2): 269-76. PubMed / Journal

Srinivasa SP, Bernstein LS, Blumer KJ, Linder ME. 1998. Plasma membrane localization is required for RGS4 function in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 95(10): 5584-9. PubMed / Journal

Stefan CJ, Overton MC, Blumer KJ. 1998. Mechanisms governing the activation and trafficking of yeast G protein-coupled receptors. Mol Biol Cell. 9(4): 885-99. PubMed / Journal

Srinivasa, SP, Watson, N, Overton, MC, Blumer KJ:  Mechanism of RGS4, a GTPase activating protein for G protein alpha subunits. 1998.  J. Biol. Chem. 273: 1529-1533 PubMed / Journal

Heximer SP, Watson N, Linder ME, Blumer KJ, Hepler JR. 1997. RGS2/G0S8 is a selective inhibitor of Gqalpha function. Proc Natl Acad Sci U S A. 94(26): 14389-93. PubMed / Journal

Watson N, Linder ME, Druey KM, Kehrl JH, Blumer KJ. 1996. RGS family members: GTPase-activating proteins for heterotrimeric G-protein alpha-subunits. Nature. 383(6596): 172-5. PubMed / Journal

Druey KM, Blumer KJ, Kang VH, Kehrl JH. 1996. Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family. Nature. 379(6567): 742-6. PubMed / Journal

Richard S, Yu D, Blumer KJ, Hausladen D, Olszowy MW, Connelly PA, Shaw AS. 1995. Association of p62, a multifunctional SH2- and SH3-domain-binding protein, with src family tyrosine kinases, Grb2, and phospholipase C gamma-1. Mol Cell Biol. 15(1): 186-97. PubMed / Journal

Grishin AV, Weiner JL, Blumer KJ. 1994. Control of adaptation to mating pheromone by G protein beta subunits of Saccharomyces cerevisiae. Genetics. 138(4): 1081-92. PubMed / Journal

Grishin AV, Weiner JL, Blumer KJ. 1994. Biochemical and genetic analysis of dominant-negative mutations affecting a yeast G-protein gamma subunit. Mol Cell Biol. 14(7): 4571-8. PubMed / Journal

Blumer KJ, Johnson GL. 1994. Diversity in function and regulation of MAP kinase pathways. Trends Biochem Sci. 19(6): 236-40. PubMed

Blumer KJ, Johnson GL, Lange-Carter CA. 1994. Mammalian mitogen-activated protein kinase kinase kinase (MEKK) can function in a yeast mitogen-activated protein kinase pathway downstream of protein kinase C. Proc Natl Acad Sci U S A. 91(11): 4925-9. PubMed / Journal

Stefan CJ, Blumer KJ. 1994. The third cytoplasmic loop of a yeast G-protein-coupled receptor controls pathway activation, ligand discrimination, and receptor internalization. Mol Cell Biol. 14(5): 3339-49. PubMed / Journal

Lange-Carter CA, Pleiman CM, Gardner AM, Blumer KJ, Johnson GL. 1993. A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf. Science. 260(5106): 315-9. PubMed

Weiner JL, Guttierez-Steil C, Blumer KJ. 1993. Disruption of receptor-G protein coupling in yeast promotes the function of an SST2-dependent adaptation pathway. J Biol Chem. 268(11): 8070-7. PubMed / Journal